PUBLISHED WORK

Selected publications - 

for a full list, please click here

for a full list of public

 

THE ETS TRANSCRIPTION FACTOR ELF1 REGULATES A BROADLY ANTIVIRAL PROGRAM DISTINCT FROM THE TYPE I INTERFERON RESPONSE

November 04, 2019

Seifert LL*, Si C*, Saha D, Sadic M, de Vries M, Ballentine S, Briley A, Wang G, Valero-Jimenez A, Mohamed A, Schaefer U, Moulton H, García-Sastre A, Tripathi S, Rosenberg BR, Dittmann M, The regulatory factor ELF1 triggers a critical wave of transcription in the antiviral response to type I interferon (2019), PLOS Pathogens, doi.org/10.1371/journal.ppat.1007634

We show that the transcription factor ELF1 provides an additional layer of the innate host response, independent from the action of type I interferons.

ATP-DEPENDENT EFFECTOR-LIKE FUNCTIONS
OF RIG-I-LIKE RECEPTORS

April 16, 2015

Yao H.*, Dittmann M.*, Peisley A., Hoffmann H.-H., Gilmore R.H., Schmidt T., Schmidt-Burgk J., Hornung V., Rice C.M. & Hur S. “ATP-dependent effector-like functions of RIG-I like receptors” (2015), Mol. Cell 58: 541-548 (* = equal contributions)


We demonstrate that RIG-I and MDA5 not only function as viral RNA receptors, but also as effector proteins by displacing viral proteins bound to RNA during ATP hydrolysis. Accordingly, RIGI/MDA5 can suppress viral replication independent of the interferon signaling.

A SERPIN SHAPES THE EXTRACELLULAR ENVIRONMENT TO PREVENT
INFLUENZA A VIRUS MATURATION

February 12, 2015

Dittmann, M., Hoffmann, H.-H., Scull, M. A., Gilmore, R.H., Bell, K.L., Ciancanelli, M., Wilson, S.J., Crotta, S., Yu, Y., Flatley, B., Xiao, J.W., Casanova, J.-L., Wack, A., Bieniasz, P.D. & Rice, C.M. “A serpin shapes the extracellular environment to prevent influenza A virus maturation” (2015), Cell 160: 631–643


Plasminogen activator inhibitor (PAI-1) blocks surface glycoprotein maturation of influenza A virus, thus reducing virus spread in the airways and revealing that the innate immune system, driven by type I IFN, uses modulation of the extracellular environment to inhibit viruses.

INTERFERON-STIMULATED GENES:
A COMPLEX WEB OF HOST DEFENSES

January 25, 2014

Schneider, W.M., Dittmann Chevillotte, M.& Rice, C.M. “Interferon-stimulated genes: a complex web of host defences” (2014), Ann. Rev. Immunol. 32: 513-545


Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production. Next, we describe ways in which ISGs both enhance innate pathogen-sensing capabilities and negatively regulate signaling through the JAK-STAT pathway. Several ISGs that directly inhibit virus infection are described with an emphasis on those that impact early and late stages of the virus life cycle. Finally, we describe ongoing efforts to identify and characterize antiviral ISGs, and we provide a forward-looking perspective on the ISG landscape.

Dittmann laboratory
Alexandria Center for Life Sciences, West Tower
430 E 29th Street, room 313
New York, New York 10016
USA

©2018 by Dittmann laboratory. Proudly created with Wix.com